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There are several causes of unevenness. Most are in the manufacturing process of the LCD panel.
The exposure is a step in the manufacturing process for the panel. It is a process to produce circuits on the glass plate of the panel. These circuits actually operate the LCD. The exposure is carried out automatically and mechanically. If the processing time is uneven, the thickness of the electrodes may be uneven in some places. Due to this unevenness, the displayed brightness becomes relatively too bright or too dark.
In the display panel of the LCD monitor, two thin glass sheets are adhered with a gap of 4 to 5 micrometers. Since the gap is very small, it may be uneven in some places. If the gap is uneven or distorted, conditions for transmitting lights may vary and then it may cause unevenness in the colors and brightness.
If the monitor is used in a place exposed to a lot of sunlight for long periods, the film on the LCD panel is tinged with yellow and the color reproduction performance will drastically deteriorate.
For the high-grade series monitors, unevenness of each monitor is compensated one by one at the factory.